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dc.contributor.authorOjeda, Jorge
dc.contributor.authorÁvila, Ariel
dc.date.accessioned2020-06-28T01:51:29Z
dc.date.available2020-06-28T01:51:29Z
dc.date.issued2019-11-21
dc.identifier.citationFrontiers in synaptic neuroscience 2019 Nov 21; Vol. 11, pp. 33es_CL
dc.identifier.issn1663-3563
dc.identifier.urihttp://repositoriodigital.ucsc.cl/handle/25022009/2050
dc.description.abstractThe development of the brain is shaped by a myriad of factors among which neurotransmitters play remarkable roles before and during the formation and maturation of synaptic circuits. Cellular processes such as neurogenesis, morphological development, synaptogenesis and maturation of synapses are temporary and spatially regulated by the local or distal influence of neurotransmitters in the developing cortex. Thus, research on this area has contributed to the understanding of fundamental mechanisms of brain development and to shed light on the etiology of various human neurodevelopmental disorders such as autism and Rett syndrome (RTT), among others. Recently, the field of neuroscience has been shaken by an explosive advance of experimental approaches linked to the use of induced pluripotent stem cells and reprogrammed neurons. This new technology has allowed researchers for the first time to model in the lab the unique events that take place during early human brain development and to explore the mechanisms that cause synaptopathies. In this context, the role of neurotransmitters during early stages of cortex development is beginning to be re-evaluated and a revision of the state of the art has become necessary in a time when new protocols are being worked out to differentiate stem cells into functional neurons. New perspectives on reconsidering the function of neurotransmitters include opportunities for methodological advances, a better understanding of the origin of mental disorders and the potential for development of new treatments.es_CL
dc.language.isoenes_CL
dc.publisherFrontiers in synaptic neurosciencees_CL
dc.source.uri https://doi.org/10.3389/fnsyn.2019.00033
dc.subjectGABAes_CL
dc.subjectCortexes_CL
dc.subjectGlutamatees_CL
dc.subjectGlycinees_CL
dc.subjectNeurodevelopmental disorderes_CL
dc.subjectNeurogenesises_CL
dc.subjectNeurotransmitterses_CL
dc.titleEarly actions of neurotransmitters during cortex development and maturation of reprogrammed neuronses_CL
dc.title.alternativeAcciones tempranas de neurotransmisores durante el desarrollo de la corteza y maduración de neuronas reprogramadases_CL
dc.typeArticlees_CL


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