Genetic variants in the SLC16A11 gene are associated with increased BMI and insulin levels in nondiabetic Chilean population
Date
2021Author
Petermann-Rocha, Fanny
Martinez-Sanguinetti, María Adela
Leiva, Ana María
Martorell, Miquel
Lasserre, Nicole
Ulloa, Natalia
Perez-Bravo, Francisco
Celis-Morales, Carlos
Mardones Leiva, Lorena Gisela
Villagrán Orellana, Marcelo Alejandro
Troncoso Pantoja, Claudia Andrea
Publisher
Archives of Endocrinology and MetabolismDescription
ArtículoMetadata
Show full item recordAbstract
Objective: To study the association of SLC16A11 gene variants with obesity and metabolic markers
in nondiabetic Chilean adults. Materials and methods: This cross-sectional study included 263 nondiabetic
adults. The genotype of the rs75493593 polymorphism of SLC16A11 gene was performed by
real-time PCR. It’s association with adiposity markers (body weight, BMI, waist circumference and fat
mass percentage), metabolic markers (glucose, insulin, HOMAIR, leptin, total cholesterol, LDLc, HDLc,
triglycerides, ALT, GGT and hsCRP) and blood pressure was analyzed by linear regression. Results:
The minor allele (T) of the SLC16A11 gene (rs75493593) has a frequency of 29.7% among Chileans.
Risk genotypes (GT and TT) were associated with a significant 1.49 mU/l increase in plasmatic insulin
for each copy of the minor allele (95% CI: 0.12, 2.87, p < 0.05). This association remained significant
after adjusting for socio-demographic variables, physical activity and smoking (1.36 mU/l, 95%
CI: 0.16, 2.58 p < 0.05), but was lost when BMI was included as a confounding factor. Higher BMI
was also significantly associated with polymorphic genotypes in SLC16A11, independent of sociodemographic
variables. Conclusion: The minor allele of the SLC16A11 gene (T) is highly prevalent
among Chileans and is associated with increased insulin and BMI in nondiabetic individuals. These
findings suggest that the genetic variant in SLC16A11 is not only associated with type 2 diabetes as
previously shown in Mexicans, but is also related to early metabolic alterations in healthy subjects
that may lead to type 2 diabetes.