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    Genetic variants in the SLC16A11 gene are associated with increased BMI and insulin levels in nondiabetic Chilean population

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    Genetic variants in the SLC16A11 gene are associated with increased BMI and insulin levels in nondiabetic Chilean population (92.12Kb)
    Date
    2021
    Author
    Petermann-Rocha, Fanny
    Martinez-Sanguinetti, María Adela
    Leiva, Ana María
    Martorell, Miquel
    Lasserre, Nicole
    Ulloa, Natalia
    Perez-Bravo, Francisco
    Celis-Morales, Carlos
    Mardones Leiva, Lorena Gisela
    Villagrán Orellana, Marcelo Alejandro
    Troncoso Pantoja, Claudia Andrea
    Publisher
    Archives of Endocrinology and Metabolism
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    Abstract
    Objective: To study the association of SLC16A11 gene variants with obesity and metabolic markers in nondiabetic Chilean adults. Materials and methods: This cross-sectional study included 263 nondiabetic adults. The genotype of the rs75493593 polymorphism of SLC16A11 gene was performed by real-time PCR. It’s association with adiposity markers (body weight, BMI, waist circumference and fat mass percentage), metabolic markers (glucose, insulin, HOMAIR, leptin, total cholesterol, LDLc, HDLc, triglycerides, ALT, GGT and hsCRP) and blood pressure was analyzed by linear regression. Results: The minor allele (T) of the SLC16A11 gene (rs75493593) has a frequency of 29.7% among Chileans. Risk genotypes (GT and TT) were associated with a significant 1.49 mU/l increase in plasmatic insulin for each copy of the minor allele (95% CI: 0.12, 2.87, p < 0.05). This association remained significant after adjusting for socio-demographic variables, physical activity and smoking (1.36 mU/l, 95% CI: 0.16, 2.58 p < 0.05), but was lost when BMI was included as a confounding factor. Higher BMI was also significantly associated with polymorphic genotypes in SLC16A11, independent of sociodemographic variables. Conclusion: The minor allele of the SLC16A11 gene (T) is highly prevalent among Chileans and is associated with increased insulin and BMI in nondiabetic individuals. These findings suggest that the genetic variant in SLC16A11 is not only associated with type 2 diabetes as previously shown in Mexicans, but is also related to early metabolic alterations in healthy subjects that may lead to type 2 diabetes.
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    http://repositoriodigital.ucsc.cl/handle/25022009/2576
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