Uric acid and purine plasma levels as plausible markers for placental dysfunction in pre-eclampsia
Date
2013Author
Escudero, Carlos
Bertoglia, Patricio
Muñoz, Felipe
Roberts, James M.
Publisher
ScieloDescription
Artículo de publicación ISIMetadata
Show full item recordAbstract
Uric acid is the final metabolite of purine break down, such as ATP, ADP, AMP, adenosine, inosine and hypoxanthine. The metabolite has been used broadly as a renal failure marker, as well as a risk factor for maternal and neonatal morbidity during pre-eclamptic pregnancies. High purine levels are observed
in pre-eclamptic pregnancies, but the sources of these purines are unknown.
However, there is evidence that pre-eclampsia (mainly severe pre-eclampsia)
is associated with an increased release of cellular fragments (or microparticles) from the placenta to the maternal circulation. These in fact could be the
substrate for purine metabolism. Considering this background, we propose that purines and uric acid are part of the same physiopathological phenomenon in pre-eclampsia (i.e., placental dysfunction) and could become biomarkers for
placental dysfunction and postnatal adverse events.