Browsing A) Producción científica UCSC by Author "Farías, Alejandro"

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Blocking the farnesyl pocket of PDEδ reduces rheb-dependent mTORC1 activation and survival of Tsc2-null cells

Estrella Armijo, Marisol; Escalona, Emilia; Peña, Daniela; Farías, Alejandro; Morin, Violeta; Baumann, Matthias; Klebl, Bert Matthias; Pincheira, Roxana; Castro, Ariel Fernando (2022)

Rheb is a small GTPase member of the Ras superfamily and an activator of mTORC1, a protein complex master regulator of cell metabolism, growth, and proliferation. Rheb/mTORC1 pathway is hyperactivated in proliferative ...